India is gaining weight. Traditionally known for malnutrition, Indians now report more and more frequently with overweight, obesity, and their consequences. Indians exhibit unique features of obesity: Excess body fat, abdominal adiposity, increased subcutaneous and intra-abdominal fat, and deposition of fat in ectopic sites (such as liver, muscle, and others). Obesity is a major driver for the widely prevalent metabolic syndrome and type-2 diabetes mellitus (T2DM). Although this phenomenon is a global one, India is unique in that it has to grapple with both over- and undernutrition at the same time. This article reviews the weight of the problem of obesity in India.

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Murraya koenigii is a culinary important plant of Indian origin, and also been a component of many formulations used in the Ayurvedic system of medicine since many centuries. A scrutiny of literature reveals some notable pharmacological activities of the plant. Carbazole alkaloids which are abundantly present in the leaves, fruits, roots and bark of this plant, have been reported for their antidiabetic, anticancer, antibacterial, anti-nociceptive and antioxidant activities. Besides these activities, the plant is described to have a wide array of therapeutic activities. Phytochemistry and pharmacology of this plant necessitates a comprehensive review of its prospects as an important therapeutic agent for the management of numerous diseases commonly affecting humans. The current review provides a detailed report of the phytochemical, pharmacological, clinical and pre-clinical works carried out on this culinary plant and also throws light on its therapeutic prospects.

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Context: Many people around the world strive to achieve younger-looking skin. This is often promised by topical treatments. Oral treatments for skin ageing have been unsuccessful due to their constituents being broken down by acid and enzymes in the gut; however several studies have shown that hydrolyzed collagen is absorbed in the gut and then delivered to skin and joints through the blood stream. Aims: The aim of this study was to determine whether an oral nutritional supplement drink containing hydrolyzed collagen and other specific ingredients reported to have antiageing properties, would have a positive effect on skin wrinkling, elasticity and hydration. Materials and Methods: A double-blind, randomized, placebo controlled clinical trial was conducted on healthy subjects to assess whether this oral supplement could improve certain specific skin properties of post-menopausal women, namely depth of facial wrinkles, skin elasticity and hydration. Results: The evidence provided here proves that the combination of specific ingredients present in this nutritional drink acts to significantly reduce the depth of facial wrinkles and increase skin elasticity and hydration. Conclusions: This study shows that the oral nutritional supplement consisting of hydrolyzed collagen, hyaluronic acid, and essential vitamins and minerals, leads to a significant improvement in wrinkle depth. It is also able to induce noticeable improvement in elasticity and hydration of the skin.

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Nutritional needs in patients with chronic kidney disease are different from those of the normal population. As such, estimation of these nutritional requirements mandates a thorough understanding of the various physiologic and pathologic processes related to renal system. Many of these patients get admitted in intensive care and dialysis units at some stage of life for one indication or the other. Intensivists also have to update their knowledge when it comes to providing nutrition to these patients during their intensive care unit (ICU) stay. Majority of these patients are on chronic dialysis and this aspect has to be taken care of while they are treated in ICU. The assessment of nutritional needs and the various dietary modifications requires the services of a nephrologist on patient-to-patient basis depending upon the underlying co-morbid diseases. Majority of the studies involving patients with renal disease have been carried out in normal population, and as such, data is lacking from ICU and dialysis units. The present article is an attempt to discuss various aspects of patients with chronic kidney disease and their nutritional needs and the relevant dietary modifications and is an extrapolation of the present evidence of normal population to the patients admitted in ICU and dialysis units.

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Obesity leads to chronic, excessive adipose tissue expansion resulting in an increase in the risk for cardiovascular disease, type 2 diabetes mellitus, and other metabolic abnormalities. This is primarily thought to stem from the low-grade, systemic inflammatory response syndrome that characterizes adipose tissue in obesity. With a global increase in the prevalence of obesity, nutrition and exercise play a key role in its prevention and treatment. Natural product (nutraceutical) interventions are currently being investigated on a large-scale basis as potential treatments for obesity and weight management. Apart from taking care of the imbalance between energy intake and energy output, nutraceuticals should have the potential to ameliorate the development of oxidative stress and inflammation in obesity, thereby limiting the onset of obesity complications. The current article aims to examine current research on nutraceuticals and their role in the management of obesity and body composition.

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Background: Owing to progressive urbanization and the associated changes in lifestyle, childhood overweight/obesity is becoming a challenging problem in many emerging countries while malnutrition is far from being over. This study, which was carried out in the school setting, therefore, aimed to compare the pattern and determinants of the weight status of school-age children from rural and urban communities of Osun State, Nigeria. Methodology: A total of 300 respondents each was selected from a rural and an urban community using multi-stage sampling technique. Information from respondents was obtained using pretested semi-structured questionnaires and their weights and heights were measured and used to calculate their body mass index (BMI). Data collection was done from September to December, 2013. The BMI was used to classify them into those underweight, normal and overweight/obese using the IOTF criteria. Data analysis was done with Statistical Package for Social Sciences (SPSS) version 16. Results: The children differed significantly in their nutrition history and activity patterns according to their residence. With the IOTF criteria, the prevalence rates of underweight and overweight/obesity in the children from rural communities were 36.7% and 0.0% respectively; and 17.3% and 9.7% in the children from urban communities, respectively. Conclusion: Underweight is still a major problem among school-age children in Osun State, especially for those living in rural communities. There is also a rising trend of overweight/obesity in the urban communities in the State. A comprehensive school health program for the primary schools with emphasis on good nutrition is hereby recommended.

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Aim: This study involves the effect of different household processing on nutritional and anti-nutritional factors in moth bean (Vigna aconitifolia) and Sorghum (Sorghum bicolour (L.) Moench) seeds and with their product development. Methods: This study involves the effect of different homemade processing of moth and Sorghum on proximate composition and anti-nutritional factors and further development of certain products using processed moth and Sorghum flours. Results: During the process of soaking, the moisture content, and vitamin C contents were found to be increased; with a significant decrease in ash content, fat content, crude fiber content, protein content in both samples (except iron content). In moth bean, 72 h germination process resulted in a decrease in moisture content, fat content, crude fiber content, with an increase in ash content, protein content, iron content, and vitamin C contents whereas in Sorgum all the contents were decreased except moisture content, and vitamin C contents. Ash content, protein content, iron content and vitamin C content with a significant decrease in moisture content, fat content, and fiber content. After processing, the anti-nutritional factors were also decreased in both samples. The modified recipes with the processed moth bean, Sorghum, and blended flours were developed as thalpeeth and papri-chat and acceptability studies of products were carried out and compared with standard. It was found that all samples were acceptable to panel members making then quality for the potential usage as delivery vehicles for use gluten allergy, scurvy, and malnourished children. Conclusion: We can conclude that moth bean and Sorghum to our diet will help to improve the nutritional profile at low cost.

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Context: Gmelina arborea Roxb (Family: Verbenaceae) is widely used in Sri Lankan traditional Ayurvedic medicine for long -term treatment of diabetes mellitus. Aims: To investigate the in vitro and in vivo antioxidant activities of the aqueous bark extract of G. arborea. Materials and Methods: The in vitro total antioxidant activities of the hot water bark extract of G. arborea were evaluated by 2,2'-diphenyl-2-picrylhydrazyl hydrate (DPPH), ferric reducing antioxidant potential (FRAP), and NO inhibition assays. The in vivo antioxidant activity was evaluated by the activities of liver enzymes, antioxidant enzymes, and extent of lipid peroxidation (LPO) in the liver of streptozotocin (STZ)-diabetic rats. Results: In vitro antioxidant assays (DPPH, FRAP, and NO) clearly demonstrated the antioxidant potential of G. arborea extract. The G. arborea extract decreased LPO by 27%; activities of alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase decreased by 29%, 23% and 29%, respectively (P < 0.05). The liver reduced glutathione, activities of glutathione reductase, glutathione peroxidase, and glutathione S-transferase of plant extract treated diabetic rats increased to 606.47 ± 8.04 μg/g liver tissue, 7.92 ± 0.75, 8.56 ± 1.00, and 7.44 ± 1.42 nmol/min/mg protein, respectively (P < 0.05). The extract was more effective than glibenclamide in restoring the hepatic antioxidant enzymes in STZ diabetic rats. Conclusions: The present investigation revealed that the bark extract of G. arborea exerts significant in vivo and in vitro antioxidant activities.

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Background: In India, human immunodeficiency virus (HIV) epidemic occurs in the population in which malnutrition is already endemic. The relationship between HIV and nutrition is multi-faceted and multi-directional. HIV can cause or worsen malnutrition due to decreased food intake, increased energy requirements, and poor nutrient absorption. Malnutrition in turn further weakens the immune system, increasing susceptibility to infections and worsening the disease impact. Materials and Methods: This interventional study was carried out in the antiretroviral therapy (ART) Centre of Topiwala National Medical College and BYL Nair Ch. Hospital, Mumbai during the period of July 2011 to February 2012. A total of 123 patients during the study period were included and a pre-designed and pre-tested questionnaire was used to collect data. Data were analyzed using Statistical Package of Social Sciences (SPSS) 16.0. Results: In the present study, out of 123 study participants taken into consideration, 47.15% were males and 52.85% were females. After nutritional counseling, the percentage of participants practice of using boiled or clean water for drinking purpose increased significantly from 30.90% to 82.12% ( P < 0.0001) and to not eat leftover food increased from 26.83% to 81.30% ( P < 0.0001). The change in mean BMI was observed to be statistically significant from baseline Visit I (20.859) to Visit III (21.916) ( P < 0.0001). Conclusion: Effects of nutritional counselling in our study groups were favourable. There were improvements in dietary practices about nutrition in people living with HIV/AIDS.

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Malnutrition is a serious issue in Pakistani society. During the past few years, many nutritional programmes have been initiated by the governmental and nongovernmental organizations. Some of these programmes focus on raising awareness among the masses while others focus on either directly supplying nutrients to the people or fortification of dietary components. However, the root of the problem-illiteracy, poverty, and socioeconomic deprivation-is still being neglected. These programmes have not yet been able to take control of the situation and Pakistan is still far behind other countries when it comes to nutrition. This article reviews the nutritional programmes in place in Pakistan, analyses their limitations and suggests a way forward.

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With the ever increasing epidemic of obesity, diabetes and hypertension among young adults, the risk of mortality and morbidity due to atherosclerotic heart disease is gradually increasing. Dyslipidemia is an additional risk factor for cardiovascular disease. Nutraceutical supplements can provide valid alternate to patients who are intolerant to statins or patients preferring alternative treatments. The combination of a lipid lowering diet and scientifically proven nutraceutical supplements can significantly reduce low density lipoprotein (LDL) cholesterol, increase LDL particle size, decreased LDL particle number decreased triglycerides and increased high density lipoprotein (HDL) particles. In addition, they address lipid induced vascular damage by suppressing inflammation, oxidative stress and immune response leading to additional antihypertension, antidiabetic properties. The current article reviews the evidence in support of different dietary supplements and their lipid lowering beneficial effects.

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There is a growing concern of vitamin D deficiency and its relationship with several extra-skeletal pathological states, ranging from immune disorders (systemic lupus erythematosus, type 1 diabetes mellitus, multiple sclerosis, inflammatory bowel diseases, and rheumatoid arthritis), cardiovascular disorders (coronary artery disease, atherosclerosis, and hypertension), infections (viral and bacterial), endocrine disorders (growth failure, infertility in males, metabolic syndrome, and type 2 diabetes mellitus), neuro-psychiatric, and neuro-degenerative disorders, renal disorders, chronic lung disorders to cancer. Besides its positive effects on the musculo-skeletal system, vitamin D has shown to take an active part in the regulation of cellular proliferation, differentiation, apoptosis, and angiogenesis. It has been shown to control approximately 3% of the human genes directly or indirectly. Although there is a strong body of evidence toward implication of vitamin& D deficiency with several extra-skeletal disorders, it remains unclear if vitamin D supplementation may slow down, halt or even reverse the disease processes. This review aims to discuss the potential associations of vitamin D with various extra-skeletal disorders.

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Background: Even after more than three decades of implementation, the success of Integrated Child Development Services program in tackling maternal and childhood problems still remains a matter of concern. The present study was conducted to evaluate nutritional and other activities at Anganwadi centers (AWCs) in different districts of Gujarat state, India. Materials and Methods: A total of 60 AWCs were selected including 46 AWCs from the rural area and 14 AWCs from the urban area during April 2012 to March 2013 from 12 districts of Gujarat. Five AWCs were selected from one district randomly. Detailed information about various nutritional activities including growth monitoring, information related to preschool education (PSE), and nutrition and health education (NHED) were collected. Results: Growth chart was present in 96.7% AWCs and accurately plotted by Anganwadi workers (AWWs) in 95.0% AWCs. Weight monitoring of children was done by using Salter scale/spring balance in 75.0% AWCs, followed by weighing pan (18.3%). Overall 18.5% moderately malnourished and 1.5% severely malnourished children were reported. PSE material was available only in 35.0% AWCs. Only in one-third AWCs, NHED training material was available in adequate quantity. Conclusion: There were gaps in the status of PSE activities in AWCs, which needs to be promptly addressed. The need for PSE should be emphasized to all AWWs. There was also a shortage of supply of PSE and NHED material at the AWCs suggesting need of regular supply of material.

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Under nutrition is still a major problem in India and at the same time overweight and obesity are also beginning to affect a substantial proportion of the population. Macro and micronutrient deficiencies affect a significant proportion of the population. Children, pregnant, and lactating women are the most affected with the retardation of cognitive and physical growth, increased susceptibility to infections which ultimately affects productivity of the country. Hence, the Government has devised several national programs like Integrated Child development services (ICDS), National Iron + initiative, National Iodine deficiency disorder control program (NIDDCP) etc., The activities under each program have been listed and its impact as assessed by various evaluation programs has also been mentioned. The determinants of under nutrition are a result of a complex interaction between various factors articulated by UNICEF as immediate, underlying, and fundamental determinants. The fact remains that inspite of all the programs, household food security is determined by a more complex array of factors. Concerted effort and a convergence by all the programs are required with particular emphasis on gender equity. More attention is required in rural areas, scheduled caste and tribe people, very young children between 0-2 years, and the girl child.

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Malnutrition is common in patients with chronic kidney disease (CKD) and is an important cause of morbidity and mortality. Assessment of nutritional status is mandatory for all CKD patients. Many tools are available for assessing the nutritional status. Patients with CKD need to follow a healthy diet plan to maintain normal protein stores and to avoid metabolic complications. This article deals with the practical aspects of nutrition in patients with CKD.

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Male sexual dysfunction (MSD) is a common and distressful condition which is often amenable to counseling and other non pharmacological therapy. These ALLIANCE guidelines are an exhaustive coverage of the counseling and related non-pharmacological methods used for management of MSD. The guidelines discuss various concepts of medical care, including the bio-psychosocial model, patient centered care, couple centered care, therapeutic patient education, shared decision making, minimizing the discomfort of change, and coping skills training, as related to MSD. They go on to describe the ideal environment and prerequisites in which a proper history should be elicited, and physical examination performed. Counseling related to investigations, physical activity and yoga is described. Specific examples of psychotherapy for various sexual disorders are presented to illustrate the usage of counseling. The guidelines discuss cognitive behavioral therapy, couple centered therapy, family therapy, and use of religion in detail. Counseling regarding pharmacological, device and invasive therapy is also covered. The guidelines conclude with a call to enhance community awareness of MSD

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Background: Infant feeding and complementary feeding practices are the determinants of growth and development. Inadequate nutrition contributes substantially to childhood death and disease. Restriction of diet during common childhood illnesses further compromises the nutritional status of the child. Objectives: The present study aims to determine the beliefs and practices among rural caregivers regarding diet during common childhood illnesses. Materials and Methods: A cross-sectional study was conducted at pediatrics department of Pravara Rural Hospital, Loni from April to June 2012 by interviewing 200 caregivers of ill children. A pre-designed and pre-tested questionnaire, which based on the beliefs and practices regarding dietary pattern in common childhood illnesses, was used to collect the data. Results were analyzed in the form of percentage and proportions whenever appropriate. Results: In this study, caregivers believed that a child must be fed less during illness. Majority (89%) believed that curd should be restricted during measles, and 69% and 72% believed that oily foods should be restricted during jaundice and fever, respectively. Feeding the child with khichadi (81.5%) was most preferred during measles, while banana (95%) was preferred food during diarrhea. About 32% preferred thinner consistency of food, and 21% believed that the breastfeeding should be decreased during illness. Conclusion: There is scope of improving feeding practices and to remove misbelieves among few caregivers. Health workers should educate elderly caregivers and mothers about the same.

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Introduction: Fish oils, containing mainly poly-unsaturated fatty acids (PUFA), are reported to be nutri-medically beneficial. There is however little or no data on the lipid contents of, and fatty acids present in, culinary fish species consumed in Umuahia, Nigeria, hence this study. Methods: The fatty acid saturation profiles and lipid contents of Scomberomorus maculatus (Mitchill, 1815), Micropogonias undulatus (Linnaeus 1766), Chrysichthys nigrodigitatus (Lacépède: 1803), Trichiurus japonicus (Temminck and Schlegel, 1844), Sardinella pilchardus (Walbaum, 1792), and Prochilodus lineatus (Valenciennes, 1836), all culinary fishes consumed in Umuahia were studied using standard procedures. Results: C. nigrodigitatus had the highest crude lipid content (21.1 ± 1.1%) followed by S. pilchardus (20.4 ± 0.6%) and P. lineatus (20.1 ± 1.0%). S. maculatus and T. japonicus had the lowest crude lipid content (~13.3% each). PUFA were most abundant in S. maculatus (40.5 ± 0.4%) and T. japonicus (39.9 ± 0.5%), but least abundant in S. pilchardus and C. nigrodigitatus (~6.0% each). Linolenic and palmitic acids were the most abundant PUFA and saturated fatty acid, respectively, in the studied fish species. Conclusion: S. maculatus and T. japonicus are the most nutri-medically desirable fishes of the six studied species.

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Prevalence of diabetes mellitus (DM) is rapidly rising throughout the globe at an alarming rate, where India leads with largest number of diabetics and became "diabetes capital of the world." Currently available conventional options for diabetes have certain limitations; considering which options from alternative resources are being searched to meet the need. Ayurveda, the traditional system of Indian subcontinent hold huge number of remedies that can be useful in the treatment of diabetes and associated complications. To revalidate the actual efficacy of these formulations in DM (~Madhumeha); many studies have been carried out at different research centers of India. The current attempt is aimed to compile such works done at two Post Graduate institutes of Gujarat Ayurved University during 2000-2013. These studies aimed at establishing the impact of various Ayurvedic treatment modalities viz. Shodhana (purification/cleansing procedures) and Shamana (pacifying medicinal treatment) etc., in DM. These therapies were found to increase quality of life, significantly effective and clinically safe as no adverse drug reactions were reported during the treatment period.

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Vitamin A deficiency is a major cause of childhood mortality and morbidity in India and other developing countries. The ocular manifestations of vitamin A are collectively called xerophthalmia and range from conjunctival xerosis to severe blinding complications such as keratomalacia. Vitamin A deficiency exists as a major public health nutrition problem among preschool-aged children, especially in the South East Asian region, as well as among the pregnant and lactating women. Deficiency can be diagnosed by the ocular manifestations such as Bitot's spots, serum retinol levels, and conjunctival impression cytology (CIC). Improving vitamin A status in the diet or by periodic administration of vitamin A to children can reduce both mortality and blindness. This review is an attempt to highlight the ocular manifestations of vitamin A deficiency, its prevalence, treatment, and preventive strategies.

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Age-related macular degeneration (ARMD) is the most common cause of severe, irreversible, vision loss in elderly people. It is estimated that 20 to 25 million people suffer from ARMD worldwide, of which 8 million people experience blindness. The treatment options are few and usually not successful in restoring the vision back. The anti-oxidants prevent the damage to the macula by free radicals and are beneficial in retarding the progress of ARMD. They also prevent the onset of ARMD. Anti-oxidant supplements are indicated to prevent the onset and retard the progression of ARMD. The Age-Related Eye Disease Study found that the daily supplementation of vitamin C 500 mg, vitamin E 400 IU and beta carotene 15 mg, zinc 80 mg and copper 2 mg for five years significantly retarded the progression of ARMD. Based on the results of this high quality, double blinded study, the American Academy of Ophthalmology recommends that patients with intermediate and severe ARMD consider taking antioxidants plus zinc on a daily basis.

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Diseases of the endocrine glands highlight the importance of hormonal and nutritional factors in the regulation of metabolism in human beings. The nutritional alterations affect each and every aspect of the functioning of the endocrine glands leading to serious disorders. The last century was marked by the classical deficiency disorders, such as goiter, cretinism, hypothyroidism, and rickets. Industrialization coupled with increased availability of junk food leads to the epidemic of different nutritional endocrine disorders, such as obesity, metabolic syndrome, and diabetes. Endocrine disruptors are the new kids on the block with a variety of implications ranging from obesity to pubertal disorders. We give a concise outlook on various nutritional endocrine disorders in this review.

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Vitamin D deficiency often presents with musculoskeletal symptoms, such as pain and weakness. These symptoms are common, presenting complaints in patients across the country, across medical specialties. This work highlights the high incidence of low vitamin D levels among 234 female patients presenting with musculoskeletal symptoms in Haryana, North India. A single center cross-sectional study was performed in patients presenting with various musculoskeletal complaints, during winter months. Analysis of 25-hydroxy vitamin D levels revealed a prevalence of vitamin D deficiency of 55.55% and insufficiency of 38.46% (combined: 94.01%).

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Objectives: To study the nutritional status of school going adolescent girls in Lucknow district, Uttar Pradesh, India. Materials and Methods: A cross-sectional descriptive study was carried out in urban as well as rural schools of Lucknow district from October 2008 to September 2009. Multistage random sampling was used to select the requisite number of girls. A total of 847 school going adolescent girls between 10 and 19 years of age were interviewed and anthropometric measurements were recorded for assessing the nutritional status. Results and Conclusions: The mean weight in all age groups in both urban and rural schools showed significant difference with the ICMR mean weight for respective ages except in ages 18 and 19 years in urban school girl's and in ages 10 and 19 years in rural school girls. The mean height in all age groups in both urban and rural schools showed significant difference with the ICMR mean height for respective ages except in ages 18 and 19 years in urban schools and in ages 16, 17, 18, and 19 years in rural schools. Overall prevalence of thinness was found to be 17.0% and 11.4% (BMI <5th percentile according to NCHS-CDC reference) among urban and rural school going adolescent girls respectively. Overall prevalence of overweight was found to be 5.4% and 3.9% (BMI >85th percentile according to NCHS-CDC reference) among urban and rural school going adolescent girls, respectively.

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