|LETTER TO THE EDITOR
|Year : 2014 | Volume
| Issue : 1 | Page : 50
Vitamin A and dermatology
Intern, Government Medical College, Patiala, Punjab, India
|Date of Web Publication||24-Dec-2013|
Government Medical College, Patiala, Punjab
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Goyal A. Vitamin A and dermatology. J Med Nutr Nutraceut 2014;3:50
In the exhaustive review on 'Vitamin A deficiency: An eye sore,' in the Journal of Medical Nutrition and Nutraceuticals,  it is also important to highlight the dermatological manifestations that occur with this deficiency and throw some light on its potential benefits as a drug in dermatology.
The dermatological findings associated with Vitamin A deficiency were first described by Lowenthal in 1993, where he linked the occurrence of polygonal papules on the extensor surfaces of the extremities bilaterally and correlated them with night blindness and xerophthalmia. Nicholas later coined these findings as phrynoderma. ,
The dermatological effects of vitamin A can be explained by a simple understanding of its physiological effects. It plays an important role in maintaining the integrity of specialized epithelial surfaces. Its deficiency leads to atrophy of the mucosa. The normal epithelium undergoes metaplastic changes and is replaced by a keratinized stratified squamous epithelium. There is also a loss of goblet cells. These changes are more predominant in tissues where the epithelial cell turnover is high, like in the skin, lungs, gastrointestinal tract, and urogenital tract.
It is because of these effects that Vitamin A finds its clinical utility in multiple dermatological conditions.
Acne - The potential use of both topical and oral isotretinoin as a drug for the treatment of acne has been recognized. ,
Lichen planus-retinoids have anti-inflammatory and immunostimulating effects. 
Psoriasis - Vitamin A has an anti-proliferative effect in hyperproliferative conditions such as in psoriasis. 
Familial pityriasis rubra pilaris - Vitamin A exerts a therapeutic effect by modulating keratinocyte differentiation, keratinocyte hyperproliferation, and tissue infiltration by inflammatory cells. 
| Conclusion|| |
It is important to highlight the importance of Vitamin A in dermatological conditions, as it is a simple and economical nutraceutical.
| References|| |
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