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ORIGINAL ARTICLE
Year : 2012  |  Volume : 1  |  Issue : 2  |  Page : 111-114

Effect of hyperglycemia on LDL oxidation in type 2 diabetic patients


1 Department of Biochemistry, G.R. Medical College, Gwalior, India
2 Department of Diabetes, Obesity and Thyroid CenterLalitpur Colony, Gwalior, India

Correspondence Address:
Nivedita Singh
Department of Biochemistry, G.R. Medical College, Gwalior, Madhya Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-019X.101302

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Type 2 diabetes is associated with an increased risk for atherosclerosis. Oxidative stress plays a key role in the onset of diabetes and in the development of vascular complications of the disease. Low-density lipoproteins (LDL) are important targets of oxidation, and oxidative modification of LDL is involved in the pathogenesis of atherosclerosis. Hyperglycemia is a major factor in the pathogenesis of atherosclerosis in diabetes. Present study has been carried out to know the sensitivity of LDL to oxidation and assessing whether hyperglycemia in diabetes mellitus is associated with increased LDL oxidation and whether these relationships are related to diabetic complications. The study was carried out in 120 diabetic subjects, classified into two groups with and without complication. LDL from the serum sample was precipitated by heparin-citrate precipitation method. The LDL fractions were exposed to oxidation with CuSO4 to measure its sensitivity to oxidation and its correlation with HbA1c was also evaluated. The present study was demonstrated that sensitivity of LDL oxidation was increased in all diabetic groups and it was positively correlated with HbA1c. In type 2 diabetes increased sensitivity of LDL for oxidation is due to hyperglycemia induced oxidative stress.


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